Meta-Analysis is the gold standard statistical approach to combine the results of multiple studies and to examine sources of heterogeneity and potential biases. This course, organised by the Population Health Exchange, will review fixed-effect and random-effects models that underlie the combination of study results in meta-analysis; the use of study-level predictors in meta-regression; assessment of small-study effects and related reporting biases; and sensitivity analyses to bias. Examples will cover meta-analysis of randomized trials and of observational studies. Throughout the course, participants will apply each model by using the R software.